NSC 143160 - Names and Identifiers
Name | 2-Chloro-3,4-diaminopyridine
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Synonyms | NSC 143160 2-Chloropyridin-3,4-diamine 2-Chloro-3,4-diaminopyridine 2-chloropyridine-3,4-diamine 2-Chloro-3,4-pyridinediam... 3,4-Diamino-2-chloropyridine 2-Chloro-3,4-pyridinediamine (4-amino-2-chloro-3-pyridyl)amine 2-chloropyridine-3,4-diaMinehydrochloride
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CAS | 39217-08-8
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InChI | InChI=1/C5H6ClN3/c6-5-4(8)3(7)1-2-9-5/h1-2H,8H2,(H2,7,9) |
NSC 143160 - Physico-chemical Properties
Molecular Formula | C5H6ClN3
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Molar Mass | 143.57 |
Density | 1.447±0.06 g/cm3(Predicted) |
Melting Point | 158-163℃ |
Boling Point | 381.3±37.0 °C(Predicted) |
Flash Point | 184.427°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 4.79±0.42(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.685 |
NSC 143160 - Risk and Safety
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R43 - May cause sensitization by skin contact
R36 - Irritating to the eyes
R22 - Harmful if swallowed
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37 - Wear suitable gloves.
S36/37 - Wear suitable protective clothing and gloves.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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UN IDs | 2811 |
WGK Germany | 3 |
HS Code | 29333990 |
Hazard Class | 6.1 |
Packing Group | Ⅲ |
NSC 143160 - Introduction
2-Chloro-3,4-diaminopyridine is an organic compound with the chemical formula C5H5ClN3. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-Chloro-3,4-diaminopyridine is a colorless crystalline solid.
-Solubility: It is soluble in water and some organic solvents, such as methanol and ethanol.
-Melting point: Its melting point is about 243-244°C.
-Stability: It is relatively stable at room temperature.
Use:
-Pharmaceutical field: 2-Chloro-3,4-diaminopyridine can be used as an intermediate for drugs. It plays an important role in some drugs, such as the treatment of leukemia and other malignant tumors.
-Organic synthesis: It can be used in organic synthesis, such as the preparation of catalysts, the synthesis of nucleotide derivatives, etc.
Preparation Method:
2-Chloro-3,4-diaminopyridine can be prepared by the following method:
1. Pyridine reacts with trichlorophosphorus cyanide to generate 2-chloropyridine;
2. 2-Chloropyridine reacts with ammonia to produce 2-Chloro-3,4-diaminopyridine.
Safety Information:
- 2-Chloro-3,4-diaminopyridine is an organic compound with certain toxicity. During handling and storage, it is necessary to comply with relevant safety operating standards.
-Avoid inhalation, ingestion or contact with skin and eyes.
-If inhalation, ingestion or skin contact occurs, rinse with water and seek medical help.
-When storing and handling 2-Chloro-3,4-diaminopyridine, avoid mixing with oxidants, strong acids and strong bases to prevent dangerous reactions.
Please note that in the process of using 2-Chloro-3,4-diaminopyridine, you should operate carefully according to the specific situation and abide by the laboratory's safe operation regulations.
Last Update:2024-04-09 15:17:58